Release Date: December 23, 2025
Expiration Date: December 23, 2026
Activity Overview
Tenosynovial giant cell tumor (TGCT) is challenging to diagnose and manage, requiring the coordination of clinicians across specialties. In this BURST CME™ activity, 2 experts in TGCT management review the current landscape of diagnosis and treatment, including discussion of the strengths and limitations of established diagnostic approaches and an exploration of the expanding therapeutic arsenal for this disease. Multidisciplinary management of TGCT is also discussed to integrate surgical, systemic, supportive, and rehabilitative care for patients.
Target Audience
This educational program is directed toward medical oncologists, orthopedic surgeons, orthopedic oncologists, radiologists, pathologists, advanced practice providers, general practitioners, nuclear medicine physicians, and other health care professionals involved in the treatment of TGCT.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Identify patients with tenosynovial giant cell tumor (TGCT) through early symptom recognition and optimal application of established diagnostic approaches
- Assess the potential clinical implications of recent data and ongoing trials of approved and emerging therapies when personalizing treatment in patients with TGCT
- Select optimal therapy according to available data, disease subtype, extent of recurrence, and other factors in patients with TGCT
- Evaluate the role of multidisciplinary strategies in advancing the management of patients with TGCT

Mark Agulnik, MD
Professor of Clinical Medicine
Vice Chair for Faculty Development, Department of Medicine
Section Chief of Sarcomas & Melanoma
Division of Medical Oncology, Department of Medicine
Keck School of Medicine of the University of Southern California
Los Angeles, CA
Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Aadi Bioscience, Boehringer Ingelheim, Daiichi Sankyo, Deciphera, SpringWorks

Lee M. Zuckerman, MD
Associate Professor
Department of Orthopaedic Surgery
Keck School of Medicine of the University of Southern California
Los Angeles, CA
Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: Deciphera, Globus Medical
The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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